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Wellbutrin consumer information

This medication may also be used to treat attention deficit hyperactivity disorder ADHD or to help people quit smoking by decreasing cravings and nicotine withdrawal effects. It may also be used along with other mood stabilizers to treat bipolar disorder depressive phase. It may also be used to treat anxiety in people with depression. Families and caregivers of patients being treated with antidepressants for major depressive disorder or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of agitation, irritability, unusual changes in behavior, and the other symptoms described above, as well as the emergence of suicidality, and to report such symptoms immediately to healthcare providers. Such monitoring should include daily observation by families and caregivers. Prescriptions for Wellbutrin XL should be written for the smallest quantity of tablets consistent with good patient management, in order to reduce the risk of overdose. brand nortriptyline online pharmacy

CGI-Improvement Scale CGI-I score

You may have a higher risk of seizures if you use certain medications together with bupropion. Your doctor may prescribe nicotine patches or gum to help support your smoking cessation treatment. Read all directions and safety information for the nicotine product. Do not smoke at any time if you are using a nicotine product along with Zyban. Too much nicotine can cause serious side effects. Store at room temperature away from light and moisture. You may notice an odor from the tablets; this is normal and does not affect how they work. not store in the bathroom. Keep all away from children and pets.

What specialists treat depression?

Take this medication by mouth, with or without food, usually three times daily. If stomach upset occurs, you may take this drug with food. It is important to take your doses at least 6 hours apart or as directed by your doctor to decrease your risk of having a seizure. Make sure you are not taking more than one product containing generic bupropion at one time, as that could result in an overdose. The mechanism of action of bupropion is unknown, as is the case with other antidepressants. Johnson syndrome, and anaphylactic shock associated with bupropion. Where can one seek help for depression?

List of wellbutrin side effects

Bupropion is used to treat depression. It can improve your mood and feelings of well-being. It may work by helping to restore the balance of certain natural chemicals neurotransmitters in your brain. Know all of the medicines that you or your family member takes. The extent of protein binding of the hydroxybupropion metabolite is similar to that for bupropion; whereas, the extent of protein binding of the threohydrobupropion metabolite is about half that seen with bupropion.



Before taking wellbutrin

Dilantin phenytoin sodium US prescribing information. Pfizer, Inc. I'm currently taking 450mg. Each increase in dosage was beneficial for about a week, but then I'd hit a plateau. 450 seemed to be the right dose for about 3 weeks, but I've been on this dose for 8 weeks now and feel like the cons are starting to outweigh the pros. I'm not as focused anymore, in fact I've began to have more apathy. My depression hasn't really been helped and I have emotional panic attacks now and then, especially if I drink alcohol-which I was told was the equivalent to completely skipping a dose. Steinbach, MB R5G 1Z7 Canada. If you are taking Wellbutrin SR for the treatment of major depressive disorder, it may take several weeks for you to feel that Wellbutrin SR is working. Once you feel better, it is important to keep taking Wellbutrin SR exactly as directed by your healthcare provider. Call your healthcare provider if you do not feel Wellbutrin SR is working for you. National Birth Defects Prevention Study NBDPS did not show an increased risk for cardiovascular malformations overall after bupropion exposure during the first trimester. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. If you have nausea, take your medicine with food. If you have trouble sleeping, do not take your medicine too close to bedtime. Tell your doctor right away if you have any of these symptoms after stopping treatment. Wellbutrin SR is not approved for smoking cessation treatment; however, it contains the same active ingredient as the smoking cessation medication ZYBAN. Serious neuropsychiatric adverse events have been reported in patients taking bupropion for smoking cessation. What are complications of depression?



How should i take wellbutrin

Use Wellbutrin with caution in the ELDERLY; they may be more sensitive to its effects. If you miss a dose of Wellbutrin, skip the missed dose and go back to your regular dosing schedule. Do not take more than 1 dose within 6 hours. Do not take 2 doses at once. WELLBUTRIN XL to other people, even if they have the same symptoms you have. Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Nerves, in a process referred to as reuptake, may recycle released neurotransmitters. Advise patients that any CNS-active drug like Wellbutrin XL tablets may impair their ability to perform tasks requiring judgment or motor and cognitive skills. Advise patients that until they are reasonably certain that Wellbutrin XL tablets do not adversely affect their performance, they should refrain from driving an automobile or operating complex, hazardous machinery. Wellbutrin XL treatment may lead to decreased alcohol tolerance. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy. Hyperglycemia, hypoglycemia, and syndrome of inappropriate antidiuretic hormone. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. In the SAD trials, 82% of patients were treated with 300 mg per day, and 18% were treated with 150 mg per day. The mean daily dose was 270 mg per day. The mean duration of bupropion exposure was 126 days. MDD trials using bupropion HCl sustained-release. There was a dose-related decrease in body weight. levothroid



Bupropion is not a controlled substance

The recommended starting dose for SAD is 150 mg once daily. After 7 days of dosing, the dose may be increased to the target dose of 300 mg once daily in the morning. Doses above 300 mg of bupropion HCl extended-release were not assessed in the SAD trials. Tell your healthcare provider right away about any side effects that bother you. HCl products for the immediate, sustained, and extended-release formulations. In some cases, a patient already receiving therapy with Wellbutrin SR may require urgent treatment with linezolid or intravenous methylene blue. If acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of hypertensive reactions in a particular patient, Wellbutrin SR should be stopped promptly, and linezolid or intravenous methylene blue can be administered. The patient should be monitored for 2 weeks or until 24 hours after the last dose of linezolid or intravenous methylene blue, whichever comes first. Therapy with Wellbutrin SR may be resumed 24 hours after the last dose of linezolid or intravenous methylene blue. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Chills, facial edema, edema, peripheral edema, musculoskeletal chest pain, photosensitivity, and malaise. Depressed patients treated with Wellbutrin SR have had a variety of neuropsychiatric signs and symptoms, including delusions, hallucinations, psychosis, concentration disturbance, paranoia, and confusion. Some of these patients had a diagnosis of bipolar disorder. axid.info podophyllotoxin



What should i avoid while taking wellbutrin

Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. However, it was withdrawn from the market in 1986 amid findings that it increased the frequency of seizures in non-depressed bulimic patients at the originally recommended dose of 400 to 600 milligrams a day. SR and call your healthcare provider right away if you get a rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, swelling of the lips or tongue, chest pain, or have trouble breathing. These could be signs of a serious allergic reaction. What are the risk factors and causes of depression? Antidepressant medicines can interact with other medicines. Know all of the medicines that you or your family member takes. Keep a list of all medicines to show the healthcare provider. Do not start new medicines without first checking with your healthcare provider. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. diovan mail order payment europe



Highlights for wellbutrin

There are no known antidotes for bupropion. SR again if you have a seizure. MAOI such as linezolid or intravenous methylene blue. The risk of administering methylene blue by non-intravenous routes such as oral tablets or by local injection or in intravenous doses much lower than 1 mg per kg with WELLBUTRIN SR is unclear. I've been taking Wellbutrin consistently for approximately 8 years now. It was the one and only anti-depressant I was even willing to try based on the possible side-effects. Thankfully, it worked for me because I know many people have to try several different types of meds before they find the right one or combination that will work for them. I do recall that it took about six weeks for many of the initial side effects to go away; tingling sensation, bad taste in mouth, mild nausea, insomnia, etc. What about self-help and home remedies for depression? Call your doctor for medical advice about side effects. Wellbutrin may interfere with certain lab tests, including urine screenings for amphetamines. Be sure your doctor and lab personnel know you are taking Wellbutrin. Symptoms such as these may be associated with an increased risk for suicidal thinking and behavior and indicate a need for very close monitoring and possibly changes in the medication. GlaxoSmithKline LLC used under license. This may not be a complete list of all interactions that may occur. Ask your health care provider if Wellbutrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.



Side effects of wellbutrin

Bupropion is primarily metabolized to hydroxybupropion by CYP2B6. Wellbutrin XL should be swallowed whole and not crushed, divided, or chewed. Do not drink alcohol while you are taking Wellbutrin. WELLBUTRIN XL is contraindicated. Tell your healthcare provider about all of your medical conditions and all the medicines you take. Tell your healthcare provider about your other medical conditions including if you: o have liver problems, especially cirrhosis of the liver. o have kidney problems. o have, or have had, an eating disorder, such as anorexia nervosa or bulimia. o have had a head injury. o have had a seizure convulsion, fit. o have a tumor in your nervous system brain or spine. o have had a heart attack, heart problems, or high blood pressure. o are a diabetic taking insulin or other medicines to control your blood sugar. o drink alcohol. o abuse prescription medicines or street drugs. o are pregnant or plan to become pregnant. o are breastfeeding. WELLBUTRIN passes into your milk in small amounts. Bupropion and its metabolites are present in human milk. In a lactation study of 10 women, levels of orally dosed bupropion and its active metabolites were measured in expressed milk. The average daily infant exposure assuming 150 mL per kg daily consumption to bupropion and its active metabolites was 2% of the maternal weight-adjusted dose. Exercise caution when Wellbutrin SR is administered to a nursing woman. It is generally agreed that acute episodes of depression require several months or longer of antidepressant treatment beyond the response in the acute episode. It is unknown whether the Wellbutrin XL dose needed for maintenance treatment is identical to the dose that provided an initial response. Periodically reassess the need for maintenance treatment and the appropriate dose for such treatment. Your dosage is based on your medical condition and response to therapy. quibron pharmacy coupon



Wellbutrin drug interactions

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. The use of MAOIs intended to treat psychiatric disorders concomitantly with Wellbutrin XL or within 14 days of discontinuing treatment with Wellbutrin XL is contraindicated. There is an increased risk of hypertensive reactions when Wellbutrin XL is used concomitantly with MAOIs. The use of Wellbutrin XL within 14 days of discontinuing treatment with an MAOI is also contraindicated. The incidence of seizure with Wellbutrin XL has not been formally evaluated in clinical trials. Ecchymosis, anemia, leukocytosis, leukopenia, lymphadenopathy, pancytopenia, and thrombocytopenia. You may use Wellbutrin XL and nicotine patches a type of nicotine replacement therapy at the same time, following the precautions below. Inform patients that some patients have experienced changes in mood including depression and mania psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, agitation, anxiety, and panic, as well as suicidal ideation and suicide when attempting to quit smoking while taking bupropion. Bupropion and its metabolites are cleared renally and may accumulate in such patients to a greater extent than usual. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. endep



Use of wellbutrin

After three days, your doctor may increase the dose to 300 mg a day, given as 100 mg three times a day, with at least a six-hour interval between doses. The extent of protein binding of the hydroxybupropion metabolite is similar to that for bupropion, whereas the extent of protein binding of the threohydrobupropion metabolite is about half that of bupropion. HCl sustained-release is approved for this use. This Medication Guide summarizes important information about Wellbutrin XL. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about Wellbutrin XL that is written for health professionals. There are no controlled trials assessing the safety of bupropion in patients with a recent history of myocardial infarction or unstable cardiac disease. This information should not be used to decide whether or not to take Wellbutrin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Wellbutrin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Wellbutrin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Wellbutrin. Antidepressants are medicines used to treat depression and other illnesses. It is important to discuss all the risks of treating depression and also the risks of not treating it. Patients and their families or other caregivers should discuss all treatment choices with the healthcare provider, not just the use of antidepressants. SR tablets may have an odor. This is normal. FDA pregnancy category C. It is not known whether bupropion will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. HI I had to comment on this. Bupropion and its metabolites are present in human milk. If you miss a dose, do not take an extra dose to make up for the dose you missed. Wait and take your next dose at the regular time. This is very important. If you have nausea, take your medicine with food. Consider the risk of untreated depression when discontinuing or changing treatment with antidepressant medications during pregnancy and postpartum. tinidazole



How to use wellbutrin

HCl sustained-release: abdominal pain, agitation, anxiety, dizziness, dry mouth, insomnia, myalgia, nausea, palpitation, pharyngitis, sweating, tinnitus, and urinary frequency. I'm currently taking 450mg. Each increase in dosage was beneficial for about a week, but then I'd hit a plateau. 450 seemed to be the right dose for about 3 weeks, but I've been on this dose for 8 weeks now and feel like the cons are starting to outweigh the pros. I'm not as focused anymore, in fact I've began to have more apathy. SR tablets should be swallowed whole and not crushed, divided, or chewed. Wellbutrin SR may be taken with or without food. Renal Impairment: There is limited information on the pharmacokinetics of bupropion in patients with renal impairment. So I will consult with doc. for "name brand" or go to another medication, tired of the merry-go-round of generics. SR needed for maintenance treatment is identical to the dose that provided an initial response. Periodically reassess the need for maintenance treatment and the appropriate dose for such treatment. The risk of seizure can be reduced if the Wellbutrin XL dose does not exceed 450 mg once daily and the titration rate is gradual. Read the Medication Guide provided by your pharmacist before you start using bupropion and each time you get a refill. If you have any questions, ask your doctor or pharmacist. SD: standard deviation; SE: standard error; LS Mean: least-squares mean; CI: unadjusted confidence interval included for doses that were demonstrated to be effective; NA: not available. The insoluble shell of the extended-release tablet may remain intact during gastrointestinal transit and is eliminated in the feces. Advise patients to notify their healthcare provider if they become pregnant or intend to become pregnant during therapy. New or worse mental health problems, such as changes in behavior or thinking, aggression, hostility, agitation, depression, or suicidal thoughts or actions. Some people had these symptoms when they began taking bupropion, and others developed them after several weeks of treatment, or after stopping bupropion. These symptoms happened more often in people who had a history of mental health problems before taking bupropion than in people without a history of mental health problems.



Does wellbutrin interact with other medications

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. It may take 4 or more weeks before you notice the full benefit of this drug. Continue to take this medication as directed by your doctor even after you feel better. Talk to your doctor if your condition does not improve or if it worsens. The efficacy of Wellbutrin XL in the prevention of seasonal major depressive episodes associated with SAD was established in 3 randomized, double-blind, placebo-controlled trials in adult outpatients with a history of MDD with an autumn-winter seasonal pattern as defined by DSM-IV criteria. Bupropion treatment was initiated prior to the onset of symptoms in the autumn September to November. Treatment was discontinued following a 2 week taper that began during the first week of spring fourth week of March resulting in a treatment duration of approximately 4 to 6 months for the majority of patients. Patients were randomized to treatment with Wellbutrin XL or placebo. The initial bupropion dose was 150 mg once daily for 1 week, followed by up-titration to 300 mg once daily. Patients who were deemed by the investigator to be unlikely or unable to tolerate 300 mg once daily were allowed to remain on, or had their dose reduced to, 150 mg once daily. The mean bupropion doses in the 3 trials ranged from 257 mg to 280 mg per day. Where can people find more information about depression? SR, stop taking the tablets and call your healthcare provider right away. WELLBUTRIN XL, go to www. Extended-Release Tablets, 150 mg of bupropion hydrochloride, are creamy-white to pale yellow, round tablets printed with "Wellbutrin XL 150" in bottles of 30 tablets NDC 0187-0730-30 and 90 tablets NDC 0187-0730-90. Wellbutrin XL can cause seizure. The risk of seizure is dose-related. The dose should not exceed 300 mg once daily. Increase the dose gradually. Discontinue Wellbutrin XL and do not restart treatment if the patient experiences a seizure. ECT is generally used only when medicines or other less invasive treatments prove to be unhelpful. It is also used when mood or psychotic symptoms are so severe that it may be unsafe to wait until drugs can take effect. Do I need a prescription for bupropion? Older adults may be more sensitive to the side effects of this drug, especially dizziness and memory loss. Dizziness can increase the risk of falling. Your dosage is based on your medical condition and response to therapy. Your dose may be slowly increased to limit side effects such as sleeplessness, and to decrease the risk of seizures. To avoid trouble sleeping, do not take this medication too close to bedtime. Let your doctor know if sleeplessness becomes a problem. NTS had study medication discontinued due to hypertension compared with none of the subjects treated with sustained-release bupropion or placebo. Monitoring of blood pressure is recommended in patients who receive the combination of bupropion and nicotine replacement. Patients should be advised that taking Wellbutrin SR can cause mild pupillary dilation, which in susceptible individuals, can lead to an episode of angle-closure glaucoma. Pre-existing glaucoma is almost always open-angle glaucoma because angle-closure glaucoma, when diagnosed, can be treated definitively with iridectomy. Open-angle glaucoma is not a risk factor for angle-closure glaucoma. Swallow Wellbutrin whole. Do not break, crush, divide, or chew before swallowing. If you cannot swallow Wellbutrin whole, contact your doctor. purchase promethazine tablets



Wellbutrin XL tablets may have an odor

This drug may also be used to treat attention deficit hyperactivity disorder ADHD or to help people quit smoking by decreasing cravings and nicotine withdrawal effects. It may be used to prevent autumn-winter seasonal depression seasonal affective disorder. This drug may also be used with other medications to treat bipolar disorder depressive phase. It may also be used to treat anxiety in people with depression. Do not take bupropion to treat more than one condition at a time. If you take bupropion for depression, do not also take this medicine to quit smoking. Just wanted to get that out there as a potential precaution for everybody. I'm fine now unless I actually died and I'm imagining this or something. just kidding I'm not dead, you are! In the SAD trials, 2 patients treated with bupropion discontinued from the study because they developed hypertension. None of the placebo group discontinued because of hypertension. However, more variability was observed in some of the pharmacokinetic parameters for bupropion AUC, C max, and T max and its active metabolites t ½ in subjects with mild-to-moderate hepatic cirrhosis. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine and does not inhibit monoamine oxidase or the reuptake of serotonin. Although not statistically significant, the AUCs for bupropion and hydroxybupropion were more variable and tended to be greater by 53% to 57% in patients with alcoholic liver disease. The differences in half-life for bupropion and the other metabolites in the 2 groups were minimal. Tell your doctor all medications and supplements you use. There are no adequate studies of Wellbutrin in pregnant women. In one study, there was no difference between Wellbutrin and other antidepressants in the occurrence of birth defects. Wellbutrin passes into breast milk and may harm a nursing baby. Breastfeeding while taking Wellbutrin is not recommended. CYP2D6 such as bupropion. Where can I get more information? If you have a seizure while taking Wellbutrin XL, stop taking the tablets and call your healthcare provider right away. Do not take Wellbutrin XL again if you have a seizure. generic lamotrigine buy pharmacy australia



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What is wellbutrin


Prescribing information for wellbutrin

Taking more than the recommended dose of bupropion may increase your risk of having a seizure. Do not take more than 150 milligrams as a single dose, and do not take more than 450 milligrams per day. Inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Wellbutrin XL and counsel them in its appropriate use. Valeant Pharmaceuticals International, Inc. This medication should not be used if you are suddenly stopping regular use of sedatives including such as drugs used to treat seizures, or alcohol. Doing so may increase your risk of seizures. tegretol

Wellbutrin adult dosage

Greatly increased energy o Severe trouble sleeping o Racing thoughts o Reckless behavior o Unusually grand ideas o Excessive happiness or irritability o Talking more or faster than usual If you have any of the above symptoms of mania, call your healthcare provider. Maculopapular rash, alopecia, angioedema, exfoliative dermatitis, and hirsutism. This distinguishes Wellbutrin from several other antidepressants, which are often associated with weight gain. This drug may make you dizzy or affect your coordination. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages. Alcohol can also increase your risk of dizziness or seizures.

Unusual thoughts or behaviors

Wellbutrin XL. Instruct patients, their families, and their caregivers to read the Medication Guide and assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. The complete text of the Medication Guide is reprinted at the end of this document. Postural hypotension, hypertension, stroke, vasodilation, syncope, complete atrioventricular block, extrasystoles, myocardial infarction, phlebitis, and pulmonary embolism. Hepatic Impairment: The effect of hepatic impairment on the pharmacokinetics of bupropion was characterized in 2 single-dose trials, one in subjects with alcoholic liver disease and one in subjects with mild-to-severe cirrhosis.

Wellbutrin brand names

Taking MAO inhibitors with this medication may cause a serious possibly fatal drug interaction. Avoid taking MAO inhibitors isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication. Instruct patients to contact a healthcare professional if such reactions occur. Bupropion is not approved for use by anyone younger than 18 years old.

The recommended starting dose for MDD is 150 mg once daily in the morning. After 4 days of dosing, the dose may be increased to the target dose of 300 mg once daily in the morning. Depressed patients treated with bupropion have had a variety of neuropsychiatric signs and symptoms, including delusions, hallucinations, psychosis, concentration disturbance, paranoia, and confusion. Some of these patients had a diagnosis of bipolar disorder. Incidence based on the number of female patients. Digestive: Infrequent were abnormal liver function, bruxism, gastric reflux, gingivitis, increased salivation, jaundice, mouth ulcers, stomatitis, and thirst. Rare was edema of tongue.

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